ENGINEERING OF CYTOLETHAL DISTENDING TOXIN B BY ITS REDUCING IMMUNOGENICITY AND MAINTAINING STABILITY AS A NEW DRUG CANDIDATE FOR TUMOR THERAPY; AN IN SILICO STUDY

The cytolethal distending toxin (CDT), Haemophilus ducreyi, is one of the bacterial toxins that have recently been considered for targeted therapies, especially in cancer therapies.CDT is an A-B2 exotoxin.Its catalytic subunit (CdtB) is capable of inducing DNA double strand breaks, cell cycle arrest and apoptosis in host eukaryotic cells.The sequen

Nuclear power plants collect and store large volumes of heterogeneous data from various components and systems.With recent advances in machine learning (ML) techniques, these data can be leveraged to develop diagnostic and short-term forecasting models to better predict future equipment condition.Maintenance operations can then be planned in advanc

CO2+O2 in situ leaching uranium mine is the representative BOSCH SKS62E22EU Compact Dishwasher - White of the third generation uranium mining and metallurgy technology in China.In terms of radiation protection, the radon emission and the effective dose of the public are significantly lower than that of the second generation uranium mining and metal

Silver nanoparticles (AgNPs), revered for their antimicrobial prowess, have become ubiquitous in a range of products, from biomedical equipment to food packaging.However, amidst their rising popularity, concerns loom over their possible detrimental effects on fetal development and subsequent adult life.This review delves into the developmental toxi

The valence transition Fall entertaining of 4f electron states in rare-earth compounds is accompanied by a discontinuous change in the Kondo temperature, an energy scale tied to the interaction of the 4f states with the conduction-band states (c-f hybridization).The c-f hybridization causes the formation of heavy quasiparticle bands and produces a